For general information on mitochondrial dynamics:
Chen, H., and Chan, D.C. (2017). Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells. Cell Metab 26, 39-48. [PDF]
Mishra, P., and Chan, D.C. (2016). Metabolic regulation of mitochondrial dynamics. J Cell Biol 212, 379-387. [PDF]
Carelli, V., and Chan, D.C. (2014). Mitochondrial DNA: impacting central and peripheral nervous systems. Neuron 84, 1126-1142. [PDF]
Mishra, P., and Chan, D.C. (2014). Mitochondrial dynamics and inheritance during cell division, development and disease. Nat Rev Mol Cell Biol 15, 634-646. [PDF]
Chan, D.C. (2012). Fusion and fission: interlinked processes critical for mitochondrial health. Annual Review of Genetics 46, 265-287. [PDF]
Chen, H., and Chan, D.C. (2009). Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet 18, R169-176. [PDF]
Chan, D. C. (2006). Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241-1252. [PDF]
Selected Publications (see full publication list on PubMed)
Zhang, T., Mishra, P., Hay, B.A., Chan, D., and Guo, M. (2017). Valosin-containing protein (VCP/p97) inhibitors relieve Mitofusin-dependent mitochondrial defects due to VCP disease mutants. Elife 6.
Liu, R., and Chan, D.C. (2017). OPA1 and cardiolipin team up for mitochondrial fusion. Nat Cell Biol 19, 760-762. PMCID: PMC5757513. [PDF]
Cao, Y.L. et al. (2017). MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature 542, 372-376. [PDF]
Shin, C.S., Mishra, P., Watrous, J.D., Carelli, V., D'Aurelio, M., Jain, M., and Chan, D.C. (2017). The glutamate/cystine xCT antiporter antagonizes glutamine metabolism and reduces nutrient flexibility. Nat Commun 8, 15074. [PDF]
Rojansky, R., Cha, M.Y., and Chan, D.C. (2016). Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. Elife 5. [PDF]
Toyama, E.Q. et al. (2016). Metabolism. AMP-activated protein kinase mediates mitochondrial fission in response to energy stress. Science 351, 275-281. [PDF]
Fahrner, J.A., Liu, R., Perry, M.S., Klein, J., and Chan, D.C. (2016). A novel de novo dominant negative mutation in DNM1L impairs mitochondrial fission and presents as childhood epileptic encephalopathy. Am J Med Genet A 170, 2002-2011. [PDF]
Chen, H., Ren, S., Clish, C., Jain, M., Mootha, V., McCaffery, J.M., and Chan, D.C. (2015). Titration of mitochondrial fusion rescues Mff-deficient cardiomyopathy. J Cell Biol 211, 795-805. [PDF]
Loson, O.C., Meng, S., Ngo, H., Liu, R., Kaiser, J.T., and Chan, D.C. (2015). Crystal structure and functional analysis of MiD49, a receptor for the mitochondrial fission protein Drp1. Protein Sci 24, 386-394. [PDF]
Liu, R., and Chan, D.C. (2015). The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1. Mol Biol Cell 26, 4466-4477. [PDF]
Mishra, P., Varuzhanyan, G., Pham, A.H., and Chan, D.C. (2015). Mitochondrial Dynamics Is a Distinguishing Feature of Skeletal Muscle Fiber Types and Regulates Organellar Compartmentalization. Cell Metab 22, 1033-1044. [PDF]
Mishra, P., Carelli, V., Manfredi, G., and Chan, D.C. (2014). Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. Cell Metabolism 19, 630-641. [PDF]
Loson, O.C., Liu, R., Rome, M.E., Meng, S., Kaiser, J.T., Shan, S.O., and Chan, D.C. (2014). The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Structure 22, 367-377. [PDF]
Ngo, H.B., Lovely, G.A., Phillips, R., and Chan, D.C. (2014). Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nature Communications 5, 3077. [PDF]
Chan, N.C., den Besten, W., Sweredoski, M.J., Hess, S., Deshaies, R.J., and Chan, D.C. (2014). Degradation of the Deubiquitinating Enzyme USP33 Is Mediated by p97 and the Ubiquitin Ligase HERC2. J Biol Chem 289, 19789-19798. [PDF]
Wang, Y.E., Marinov, G.K., Wold, B.J., and Chan, D.C. (2013). Genome-wide analysis reveals coating of the mitochondrial genome by TFAM. PloS One8, e74513. [PDF]
Loson, O.C., Song, Z., Chen, H., and Chan, D.C. (2013). Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Mol Biol Cell24, 659-667. [PDF]
Chan, D.C. (2012). Fusion and fission: interlinked processes critical for mitochondrial health. Annual Review of Genetics 46, 265-287. [PDF]
Pham, A.H., McCaffery, J.M., and Chan, D.C. (2012a). Mouse lines with photo-activatable mitochondria to study mitochondrial dynamics. Genesis 50, 833-843. [PDF]
Pham, A.H., Meng, S., Chu, Q.N., and Chan, D.C. (2012b). Loss of Mfn2 results in progressive, retrograde degeneration of dopaminergic neurons in the nigrostriatal circuit. Hum Mol Genet 21, 4817-4826. [PDF]
Chan, D.C., and Schon, E.A. (2012). Eliminating mitochondrial DNA from sperm. Dev Cell 22, 469-470. [PDF]
Zhang, Y., Chan, N.C., Ngo, H.B., Gristick, H., and Chan, D.C. (2012). Crystal structure of mitochondrial fission complex reveals scaffolding function for mitochondrial division 1 (Mdv1) coiled coil. J Biol Chem 287, 9855-9861. [PDF]
Aravin, A.A., and Chan, D.C. (2011). piRNAs meet mitochondria. Dev Cell 20, 287-288. [PDF]
Ngo, H.B., Kaiser, J.T., and Chan, D.C. (2011). The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA. Nature structural & molecular biology 18, 1290-1296. [PDF]
Chan, N.C., Salazar, A.M., Pham, A.H., Sweredoski, M.J., Kolawa, N.J., Graham, R.L., Hess, S., and Chan, D.C. (2011). Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy. Hum Mol Genet 20, 1726-1737. [PDF]
Chen, H., Vermulst, M., Wang, Y.E., Chomyn, A., Prolla, T.A., McCaffery, J.M., Chan, D.C. (2010). Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutation. Cell 141, 280–289. [PDF]
Ban, T., Heymann, JA., Song, Z., Hinshaw, JE., Chan, D.C. (2010). OPA1 disease alleles causing dominant optic atrophy have defects in cardiolipin-stimulated GTP hydrolysis and membrane tubulation. Hum Mol Genet. [PDF]
Song, Z., Ghochani, M., McCaffery, J.M., Frey, T.G., and Chan, D.C. (2009). Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell 20, 3525-353. [PDF]
Detmer, S.A., Velde, C.V., Cleveland, D.W., and Chan, D.C. (2008). Hindlimb gait defects due to motor axon loss and reduced distal muscles in a transgenic mouse model of Charcot-Marie-Tooth type 2A. Hum Mol Genet 17, 367-375. [PDF]
Zhang, Y., and Chan, D.C. (2007). Structural basis for recruitment of mitochondrial fission complexes by Fis1. Proc Natl Acad Sci U S A 104, 18526-18530. [PDF]
Detmer, S.A., and Chan, D.C. (2007). Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 8, 870-879. [PDF]
Chen, H., McCaffery, J.M., and Chan, D.C. (2007). Mitochondrial fusion protects against neurodegeneration in the cerebellum. Cell 130, 548-562. [PDF]
Song, Z., Chen, H., Fiket, M., Alexander, C., and Chan, D.C. (2007). OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. J Cell Biol 178, 749-755. [PDF]
Chan, D.C. (2007). Mitochondrial dynamics in disease. The New England Journal of Medicine 356, 1707-1709. [PDF]
Detmer, S. A., and Chan, D. C. (2007). Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations. J Cell Biol 176, 405-414. [PDF]
Chan, D. C. (2006). Mitochondria: dynamic organelles in disease, aging, and development. Cell 125, 1241-1252. [PDF]
Chan, D. C. (2006). Mitochondrial fusion and fission in mammals. Annu Rev Cell Dev Biol 22, 79-99. [PDF]
Griffin, E. E., Detmer, S. A., and Chan, D. C. (2006). Molecular mechanism of mitochondrial membrane fusion. Biochim Biophys Acta 1763, 482-489. [PDF]
Griffin, E. E., and Chan, D. C. (2006). Domain interactions within Fzo1 oligomers are essential for mitochondrial fusion. J Biol Chem 281, 16599-16606. [PDF]
Chen, H., and Chan, D. C. (2005). Emerging functions of mammalian mitochondrial fusion and fission. Hum Mol Genet 14 Spec No. 2, R283-289. [PDF]
Griffin, E. E., Graumann, J., and Chan, D. C. (2005). The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria. J Cell Biol 170, 237-248. [PDF]
Chen, H., Chomyn, A., and Chan, D. C. (2005). Disruption of fusion results in mitochondrial heterogeneity and dysfunction. J Biol Chem 280, 26185-26192. [PDF]
Suntoke, T. R., and Chan, D. C. (2005). The fusion activity of HIV-1 gp41 depends on interhelical interactions. J Biol Chem 280, 19852-19857. [PDF]
Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., and Chan, D. C. (2004). Structural basis of mitochondrial tethering by mitofusin complexes. Science 305, 858-862. [PDF]
Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., and Youle, R. J. (2004). Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol 164, 493-499.
Chen, H., and Chan, D. C. (2004). Mitochondrial dynamics in mammals. Curr Top Dev Biol 59, 119-144. [PDF]
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., and Chan, D. C. (2003). Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 160, 189-200. [PDF]
Koshiba, T., and Chan, D. C. (2003). The prefusogenic intermediate of HIV-1 gp41 contains exposed C-peptide regions. J Biol Chem 278, 7573-7579. [PDF]
Chan, D. C., and Kim, P. S. (1998). HIV entry and its inhibition. Cell 93, 681-684. [PDF]
Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998). Evidence that a prominent cavity in the coiled coil of HIV type 1 gp41 is an attractive drug target. Proc Natl Acad Sci U S A 95, 15613-15617. [PDF]
Malashkevich, V. N., Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998). Crystal structure of the simian immunodeficiency virus (SIV) gp41 core: conserved helical interactions underlie the broad inhibitory activity of gp41 peptides. Proc Natl Acad Sci U S A 95, 9134-9139. [PDF]
Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997). Core structure of gp41 from the HIV envelope glycoprotein. Cell 89, 263-273. [PDF]